HI
Just curious if anyone has had successful pregnancy with compound hetero mthfr and what did you do to achieve this?

Thanks,
Nicky

Hi labbie123,

I'm not a doctor but I am an MTHFR patient. Hopefully I get all of this information right. If not, the ladies here possess an amazing amount of knowledge and can clarify anything. Also, check out (and possibly join):

http://health.groups.yahoo.com/group/immunologysupport/

MTHFR mutations come in two forms: A1298C and C677T. If you have one copy of one mutation, you are "heterozygous for A1298C" or "heterozygous for C677T", depending on which one you have. If you have one of each, you are "compound heterozygous for MTHFR mutations". If you have two copies of one mutation, you are "homozygous for A1298C" or "homozygous for C677T". According to Dr. Beer (a world-leading reproductive immunologist you'll read a lot about on this board), this is the order of severity of the different mutations:

1.) most significant = homozygous for C677T
2.) next most significant = compound heterozygous
5.) least significant = heterozygous for A1298C

I know that "homozygous for A1298C" and "heterozygous for C677T" are numbers 4 and 5 in terms of significance, but I can't remember which order...
These mutations are associated with blood clotting, and a tendancy for your blood to clot up in the teeniest, tiniest blood vessels in your body. And guess where those are... the uterus. So, YES, that could be the reason for your two miscarriages (I'm so sorry to hear about them.) But, if you take the baby aspirin and Folgard, and *possibly* Lovenox (low molecular weight heparin) you are NOT at risk for additional miscarriages, any more than the average woman (remember, first-trimester m/c's can be caused by a variety for factors unrelated to the mother.) If possible, I highly recommend seeking out a consultation with a reproductive immunologist to clarify whether other tests are needed or Lovenox should be prescribed.

Dr. Beer's rule of thumb is that for one copy of one mutation, you take 2.2 mg of Folgard (prescription Folic Acid... just taking over-the-counter Folic Acid won't do) and for two copies, whether they are of the same mutation or different mutations, you take 4.4 mg of Folgard. This is for the rest of your life, not just related to fertility. YOU ALSO NEED TO TAKE ONE BABY ASPIRIN EVERY DAY for the rest of your life.

There is no risk of birth defects related to this mutation as long as you take your prescription Folic Acid.

I'm compound heterozygous myself, so I take two tablets (4.4 mg) of Folgard, along with one daily baby aspirin. In my case, I'll also be taking Lovenox starting on cycle day 6 when I'm allowed to try again.

I hope this has been helpful and not more confusing. Don't hesitate to look up "homozygous MTHFR" on google.com or other search engines. So much information is available today.

Ladies, did I get it all correct? Please clarify if not.

Best wishes to you for a successful journey to parenthood.
I found this when I did a goggle search.
1.) most significant = homozygous for C677T- this is the one that I have. i have two children, (6 losses as well) achieved with just baby aspirin. I didn't find out that I had this until I was in the middle of my last pg.
We plan to have one more and I will insist on lovenex/heperin injections. good luck to you. :hug: