Ruth41
05-18-2006, 11:44 AM
Ladies,
I just learned about a major breakthrough in IVF that I want to pass on to you so you can discuss it with your doctors. My experience is that we women tend to pass this info on quicker than the doctors find out about it on their own, since generally they get their new info from attending an annual seminar. For some of us, a year is too long to wait! Please respond to this if your doctor already knows and uses this test, as well as any more info you can provide. Here it is:
There is a non-invasive test called an Embryo Marker Expression Test (EMET). This test is performed on the culture media surrounding early embryos and is highly predictive of the ability of individual embryos to successfully produce a pregnancy via IVF.
The EMET test measures the concentration of a genetic marker called sHLA-G (which stands for soluble human leukocyte antigen). sHLA-G is produced by the embryo and can be measured from the culture medium (embryos have to each be cultured separately!). Embryos dervied from culture media showing high concentration s of sHLA-G "exhibited improved cleavage and implantation rates". This means they can now determine which embryos will have the better chance for successful implantation! This is very exciting.
It may push PGD testing aside. In one article I read it also said that they were surprised to see that some embryos that looked perfect, were in fact not good implanters and others that looked bad, but had hgih sHLA-G went on to achieve pregnancies! Very encouraging.
The results are supposed to be in the July issue (Vol 9, No. 1) of the Journal of Reproductive BioMedicine under the title, "sHLA-G Expression in Supernatants of Individually Cultured 46-hour Embryos: A Potentially Valuable Indicator of Embryos Competency and IVF Outcome". The website is rbmonline.com.
The study's author, Dr. Geoffrey Sher, is the Founder of the Sher Institute for Reproductive Medicine. More information, articles, etc. can be found on the SIRM website.
Please please pass this information on.
I just learned about a major breakthrough in IVF that I want to pass on to you so you can discuss it with your doctors. My experience is that we women tend to pass this info on quicker than the doctors find out about it on their own, since generally they get their new info from attending an annual seminar. For some of us, a year is too long to wait! Please respond to this if your doctor already knows and uses this test, as well as any more info you can provide. Here it is:
There is a non-invasive test called an Embryo Marker Expression Test (EMET). This test is performed on the culture media surrounding early embryos and is highly predictive of the ability of individual embryos to successfully produce a pregnancy via IVF.
The EMET test measures the concentration of a genetic marker called sHLA-G (which stands for soluble human leukocyte antigen). sHLA-G is produced by the embryo and can be measured from the culture medium (embryos have to each be cultured separately!). Embryos dervied from culture media showing high concentration s of sHLA-G "exhibited improved cleavage and implantation rates". This means they can now determine which embryos will have the better chance for successful implantation! This is very exciting.
It may push PGD testing aside. In one article I read it also said that they were surprised to see that some embryos that looked perfect, were in fact not good implanters and others that looked bad, but had hgih sHLA-G went on to achieve pregnancies! Very encouraging.
The results are supposed to be in the July issue (Vol 9, No. 1) of the Journal of Reproductive BioMedicine under the title, "sHLA-G Expression in Supernatants of Individually Cultured 46-hour Embryos: A Potentially Valuable Indicator of Embryos Competency and IVF Outcome". The website is rbmonline.com.
The study's author, Dr. Geoffrey Sher, is the Founder of the Sher Institute for Reproductive Medicine. More information, articles, etc. can be found on the SIRM website.
Please please pass this information on.